Our wake-promoting treatment plan is a comprehensive one: 1. Prevention of various complications: this is a prerequisite for the awakening of patients in long-term coma, prevention of decubitus ulcers, pulmonary infections, malnutrition, hyperthermia, epilepsy, misaspiration, etc. 2.Promotional drugs: mainly include four major categories, dopamines such as levodopa, bromocriptine, amantadine; psychostimulants such as pemoline and methylphenidate; antidepressants such as protriptyline and fluoxetine; and naloxone. 3. Discontinue certain antiepileptic drugs such as phenytoin sodium and barbiturates. 4.Surgical treatment of hydrocephalus 5.Music therapy 6.Hyperbaric oxygen therapy 7.External stimulation 8.Acupuncture and neuroelectric stimulation 9.Neural cell transplantation 10.Deep electrical stimulation. Vegetative and long-term coma is a common situation that I usually encounter, and it is also one of the current research topics. The above are some of the methods used by our department to promote wakefulness, and I hope that some knowledge in this area will be helpful to you.