According to some studies in recent years, environmental factors are directly or indirectly involved in the pathogenesis of Parkinson’s disease, because the causative factors act on the human body in ways and pathways closely related to occupation and life, thus leading to the occurrence of Parkinson’s disease. The environmental factors that directly affect the pathogenesis of Parkinson’s disease are: 1. Organic chemical substances: Some drug users ingest impurities such as N-methyl-4 phenyl-1,2,3,6 tetrahydropyridine (MPTP), and the manifestations of primary Parkinson’s disease occur similarly. It can be inhaled through the lungs and can enter the body to selectively damage the nigrostriatal pigment neurons, so that people and animals produce clinical manifestations similar to Parkinson’s disease. 2, water pollution: according to reports from some industrialized countries, the occurrence and prevalence of Parkinson’s disease has a certain regional, and the water in these regions apparently contains some water-soluble substances related to the disease. 3, pesticides and industrial pollution: the onset of Parkinson’s disease and the use of pesticides are closely related to each other. Some people have even experimentally confirmed that a herbicide and MPTP has a similar molecular structure. Chemical, pharmaceutical, tannery and other industrial production processes produce some substances and Parkinson’s disease also have a potential relationship. How environmental factors affect the occurrence of Parkinson’s disease is still a topic that needs to be addressed in future medicine.