How do you take hormones? For those who suffer from rheumatological diseases, many of you may use hormones in the treatment process, but at what time do you take hormones? At what time can you take hormones to achieve the best therapeutic effect and at the same time reduce the harm to human body? The secretion of hormones is regulated by the hypothalamus, which is one of the rhythmical centers of the human body, and its hormone synthesis and secretion are in a 24-hour cycle with rhythmic changes, such as the most secretion in the morning and the least at night. The content of hormones in human plasma starts to increase from 2-4 o’clock in the morning, reaches the top at 8-10 o’clock, and then gradually decreases to the lowest at around 10 o’clock at night. When prednisone is taken orally at 5-7.5 mg per day, it inhibits the secretion of endogenous hormones by the adrenal glands. Therefore, doctors need to weigh the pros and cons of all hormone doses and regimens, protect the human biological clock, and try to arrange for a single dose in the morning, with the smallest possible dose to maintain, so that the damage to the human body can be minimized.