The most common diseases that cause anal leukoplakia include vitiligo and perianal sclerosing moss. It is a chronic inflammatory skin disease that may be related to microbial infections, endocrine, genetic and autoimmune conditions, etc. It is common for patients to have white, thinning perianal skin, which is asymptomatic at first or may be accompanied by itching. If the anal atresia is white and itchy, prompt medical attention is recommended.