For patients who have been tested for fatty liver, how to treat it is their main concern. Many fatty liver patients will blindly take all kinds of health care products, the result is that not only can they not control their condition, but also threaten their health. Moreover, fatty liver is closely related to obesity, diabetes and hyperlipidemia, and the lesion of someone’s liver may be aggravated after improper application of health supplements. For children with fatty liver, parents should not easily give them health care products with unknown efficacy, if once caused a large amount of fat accumulation in the liver of the child, it is more likely to lead to necrosis of liver cells, the development of liver fibrosis and cirrhosis. Therefore, health supplements should be taken under the guidance of a doctor. Lack of targeted and effective drugs for fatty liver Most scholars believe that the treatment of fatty liver focuses on lifestyle changes, such as dieting, exercise, alcohol prohibition and smoking cessation, removing the causes and treating the primary disease. Drugs are selected according to the different stages of fatty liver development, clinical manifestations and laboratory test results as appropriate. The main principles are: removal of etiology and causative factors, discontinuation of hepatotoxic drugs and avoidance of exposure to hepatotoxic substances, and correction of intestinal flora disorders. Enterogenic endotoxemia is closely related to the progression of fatty liver disease. Application of microecological agents and, when necessary, antibiotics that inhibit intestinal flora can reduce the ectopic intestinal flora, inhibit endotoxin production, alleviate endotoxemia and reduce the release of inflammatory factors, but the toxic side effects of drugs should be carefully considered. Control of primary underlying diseases or concomitant diseases insulin resistance and disorders of glucolipid metabolism produced by increased free fatty acids are among the causes of fatty liver formation. Active improvement of insulin resistance and abnormal glucolipid metabolism can stop the development of hepatocytes from steatosis to steatohepatitis. And reducing cholesterol and fatty acid synthesis by inhibiting the activity of rate-limiting enzymes that synthesize cholesterol is also an important measure to stop the progression of fatty liver. Oxygen stress/lipid peroxidation is another major factor in the progression of fatty liver disease, which is the key to the development of steatosis to steatohepatitis. Therefore, protecting hepatocyte membranes and improving the antioxidant capacity of hepatocytes can reduce intrahepatic fat content, promote fatty liver regression, and prevent hepatitis, necrosis and fibrosis in order to stop the progression of chronic liver disease, which is of positive significance for the remission or delay of the disease. In fact, so far there is no panacea for fatty liver disease at home and abroad, and to prevent and control obese fatty liver such modern urban diseases, weight loss through diet and exercise is more important than liver-protective drug therapy, especially simple obese fatty liver treatment is mainly to change the lifestyle, which is also the only effective choice for treatment in simple fatty liver, but for those who are not relieved after more than 3 to 6 months of treatment, attention should be paid to. Whether the primary etiology or causative factors are still at play; the causative factors are unclear as well as the condition has progressed to steatohepatitis. Hepatoprotective drugs are used as adjuvant therapy for those who have persistent clinical abnormalities in serum transaminases or inflammation, necrosis and fibrosis on liver biopsy; cryptogenic fatty liver with unknown primary cause after comprehensive examination; simple fatty liver with 6 months of basic treatment still ineffective or the basic treatment used may induce and lead to deterioration of liver disease. The main way of medication is to choose one or two liver-protective drugs for more than six months, or until the serum transaminases return to normal and imaging examinations suggest that the fatty liver has subsided. In a few patients, even if the cause is removed, the course of the disease can still progress to irreversible cirrhosis.