Ear circumference depression is one of the symptoms of pediatric Diegeorg’s syndrome. The facial features of pediatric Diegeorg’s syndrome include a long face, bulbous nasal tip and narrow nasal wings, cleft palate, flattened cheekbones, widened eye spacing, slanted eyes, low hanging ears with depressed ear circumference, and small jaw. Due to fetal hypoparathyroidism and hypocalcemia, neonates develop torsades de pointes and hypocalcemia tends to resolve within the first year of life. The child presents with peculiar facial features such as widened orbital distance, low and incised earwalls, short jaw size in the median longitudinal groove of the upper lip and nasal cleft. Large vessel abnormalities such as tetralogy of Fallot and right aortic arch are often present. If death does not occur during the neonatal period, various severe viral and fungal infections such as Candida and Pneumocystis carinii can occur during the first 3 to 4 months of life, while bacterial infections are less severe. Vaccination with live attenuated viral vaccines such as cowpox vaccine and measles vaccine and bacterial live vaccine such as BCG vaccine are prone to severe reactions and even death when injected, which is due to loss of cellular immune function. So how to check? When immunodeficiency is suspected, laboratory screening tests should be performed, including complete blood count and sorting count and platelet count; determination of IgG, IgM and IgA concentrations; antibody function assay; and clinical and laboratory judgment of infection.