Parenchymal nodules are a concept that refers to the filling of tissue cells inside normal body organ tissues as opposed to cystic nodules which are hollow inside or contain fluidic lesions. There are benign nodules and malignant nodules, and the common sites of occurrence are breast, thyroid, lung, liver, etc. For solid nodules occurring in different organs and tissues, timely determination of benign and malignant nodules is very important for the prognosis and subsequent treatment of patients. In clinical practice, the diagnosis can be clarified by means of imaging techniques such as palpation, ultrasound examination, CT examination, and MRI examination. Once a patient is diagnosed with a solid nodule, symptomatic treatment is required depending on the size and location of the nodule. If it is a relatively small solid nodule with superficial location, most of them are benign lesions. If the nodule grows too fast, surgical excision can be considered if necessary. If it is a large solid nodule with a deeper location, causing pressure on the surrounding blood vessels or organs, one should be alert to whether cancer has occurred. In this case, patients are recommended to take surgical methods to remove the nodules, and if necessary, adjuvant radiotherapy and chemotherapy can be applied to control the progress of the nodules, improve the patient’s survival quality and prolong the patient’s survival period.