There are many grades of breast nodules, and in clinical practice, they are currently differentiated by breast ultrasound, mammography, and magnetic resonance imaging. According to the breast BI-RADS grading scale, breast nodules are classified into 6 grades, of which grade 4 is divided into three subgrades A, B and C. In terms of positive predictive value for breast cancer, category 4A considers the possibility of malignant lesions, although the risk of progression is relatively low, and category 4C indicates a high risk of breast cancer. Breast nodule 4a is currently the grade at which the risk of breast cancer begins to increase and the chance of having cancer is about 20-40%. 4a does not yet have the morphologic features of typical breast cancer and has suspicion of suspected malignancy. A tissue biopsy of breast nodule grade 4 is recommended. Imaging findings of breast nodules 4a include: having asymmetrical microscopic or faint bumpy contours, irregular morphology, aspect ratio greater than or equal to 1, indeterminate microcalcifications, and round or oval non-cystic cloudiness. Women with breast nodules must develop a good lifestyle as well as work and rest habits in daily life, get enough sleep, avoid staying up late, maintain a relaxed state of mind, actively engage in physical exercise, improve their immunity, and regulate the endocrine disorders of the organism. The possibility of malignant change exists in breast nodules 4a, so patients must follow medical advice to do a good review to prevent further malignant change of the disease.