In early 2009, Ms. Chan, a 56-year-old housewife from Hong Kong who usually likes to play mahjong with friends and go out with her husband, experienced muscle pain in her limbs for no apparent reason and was depressed, disinterested, and lost pleasure. In early 2009, Ms. Chen went to the neurology department of the general hospital for general muscle pain, and no abnormality was found after ECG, EMG, and cranial MRI examinations, and the doctor prescribed painkillers for treatment, which had no obvious effect for about 1 month; after that, Ms. Chen’s husband took her on a trip to Guangxi, trying to make her feel more relaxed and help her relieve the pain caused by the pain, but during the trip Ms. Chen was not the least bit interested, and always felt muscle pain all over her body, sometimes so painful that she did not want to get up. So it went to a general hospital in Nanning, Guangxi for treatment, and there was no obvious effect, and the tour was a bust, and the patient felt sorry for her husband and felt even worse. Then the patient went around to seek medical help and repeatedly consulted on her pain problem, thinking that the pain was solved, her mood would be better and everything would be fine. For almost a year, she went back and forth to various general hospitals for consultation and treatment process, and did cranial imaging, biochemical, immunological and other tests without finding any abnormalities. The problem of muscle pain throughout her body kept bothering her and caused her great pain in her daily life. At the end of 2009, she was referred to our clinical psychology department by a friend, and the doctor diagnosed that Ms. Chen was suffering from depression. After giving antidepressant system treatment, the patient’s interest recovered, her mood turned better, and her somatic pain symptoms were soon relieved, and after her discharge, the patient re-traveled to Guangxi Guilin and other places with her husband and was in a very happy mood. In the course of clinical work, we found that depression is often characterized by various somatic discomfort and vegetative symptoms, such as headache, dizziness, palpitations, chest tightness, shortness of breath, numbness of the limbs and nausea and vomiting, etc. Patients often go to internal medicine, neurology and traditional Chinese medicine departments for medical treatment, but they often cannot find out what is wrong. The long-standing somatic pain or discomfort makes patients overly sensitive and concerned about their physical changes. They are not aware of their mood changes or believe that somatic diseases cause depressed mood. How should one distinguish depression from general physical illness? Two criteria are given here to determine this. Patients show physical discomfort but no corresponding organic disease or organ damage is detected, i.e., first of all, somatic organic disease should be excluded. There are also depressive symptoms, which are manifested as: unhappiness, lack of interest, and lack of energy, which are the three core symptoms of depression, and the symptoms should last for at least two weeks. If the above criteria are met, then the patient is likely suffering from depression and should be seen by a psychiatrist as soon as possible to avoid delaying the best time for treatment. Patients with depression do not always have thoughts of suicide; only a small percentage want to die, and many others are very afraid of death. Some people with mild depression can do things like ordinary people, without any apparent problems, but their inner ability to experience pleasure is impaired, they have no fun, no confidence and are miserable. I hope every reader will take 10 minutes a day to care for their emotions and their bodies, and talk to “them”! You will have unexpected rewards.