Can general anesthesia cause cognitive deficits in young children?

  Researchers say that receiving anesthesia at a young age does not trigger long-term cognitive problems. The results of the first randomized group anesthesia trial in children show that such brief anesthesia does not cause developmental deficits. The results come just weeks after a team of medical advisers reiterated their concerns about children being exposed to such drugs before the age of 4. Previously, many animal and human studies had discussed the relationship between such exposure and cognitive impairment, but there were no hard and fast criteria for humans and no randomized controlled trials to exclude other variables to explain the link.  This is a “reassuring finding, but not the final answer.” Dean Andreopoulos, chief anesthesiologist and anesthesiologist at Texas Children’s Hospital, said the findings are “reassuring, but not definitive. Dean Andropoulos, who was not involved in the study, said. He was not involved in the study. The new study only evaluated children’s responses to shorter periods of anesthesia, so prolonged and repeated exposure to anesthetic drugs may still cause neurodevelopmental problems. Children exposed to anesthesia may also have neurological damage, but these cannot be measured until they are older.  The study followed more than 500 infants and children who underwent hernia repair surgery across the United States, Australia, the United Kingdom, Canada, the Netherlands, New Zealand and Italy. The surgery averaged about an hour, with about half of the randomly selected children receiving general anesthesia and the other half having local anesthesia throughout the surgery. The children were all under 60 weeks and the location of the surgery and whether they were premature were recorded.  Many of the young children were operated on for a short period of time, similar to that in this trial. However, there are still many unanswered questions about the effect of these short periods of anesthesia on brain function later in life. To test whether short-duration anesthesia causes brain damage, those children will undergo another series of memory and cognitive tests at age 5 to look for small cognitive differences that may not have manifested themselves at an early age, Davidson said: “Some aspects of cognitive development such as higher executive functions, reasoning ability and memory – those are things that have to be tested at an older age. -all of which are not acquired until older ages.”  While most children are largely healthy early on and have not undergone surgical or diagnostic procedures, at least 500,000 children under the age of 3 receive anesthesia each year. Many experiments are examining the effects of this surgical experience on long-term neurocognition. At the same time, researchers are looking for alternatives to anesthesia, or ways to mitigate the neurological damage caused by it.  Scientists are also trying to determine how to assess the real-life impact of a child’s potential neurological deficits caused by anesthesia. lower scores on IQ tests or other cognitive measures do not actually affect a child’s normal life. Yet developmental experts are concerned that if such deficits are prevalent in children who receive anesthesia early in life, they could have a stacking effect.  So far, studies looking at young children who underwent surgery early have been divided in their findings, and none can definitively answer whether the anesthesia itself damaged the brain, or whether there were other hidden problems at play, such as very sick children who needed surgery and whose illnesses also caused cognitive problems. This new study at least helps answer that question.