Whether or not pre-diabetes requires medication needs to be judged according to the patient’s condition, most do not need to take medication, but need to control blood sugar through diet and exercise. Usually pre-diabetes refers to the state between normal glucose homeostasis and diabetic hyperglycemia, which means that the blood glucose exceeds the normal range but does not reach the diagnostic standard of diabetes. Patients usually have no obvious discomfort symptoms and clinical manifestations, and rely only on testing blood glucose to find out. Pre-diabetic patients generally do not need to be treated with medication, and need to regulate their blood glucose through active dietary control and exercise first. If there is no significant improvement or increase in blood glucose after diet and exercise, patients need to take medication as prescribed by the doctor. There are many commonly used hypoglycemic drugs, such as insulinotropic agents like gliclazide, glipizide, repaglinide, non-insulinotropic agents such as metformin, rosiglitazone, acarbose, DPP-4 inhibitors such as vigabatrin, saxagliptin, etc, or SGLT-2 inhibitors such as dapagliflozin, engelezin, etc. Meanwhile, patients can also be treated by injections of glycerin, saxagliptin and other drugs to reduce blood glucose. Meanwhile, patients can also be treated with insulin injections such as glucagon, glargine insulin, lysine insulin, and GLP-1 receptor agonists such as exenatide and benalutide. It is recommended that pre-diabetic patients should follow a reasonable treatment plan under the guidance of their doctors according to their own conditions.