The patient was a male, 37 years old. Admitted to the hospital on December 29, 2010 for the following main reasons: dry throat, sore throat with runny nose for more than 10 days, cough, cough sputum, fever for 6 days. Diagnosis: severe influenza A (H1N1), severe pneumonia, type I respiratory failure, acute pulmonary sepsis, abnormal coagulation function, abnormal liver function. The patient had dry throat, sore throat with runny nose after exertion, no fever, no cough, tightness of breath, coughing and coughing up sputum 6 days ago, sputum was white sputum, tightness of breath, and she was taking “Cold and Flu Capsules, Vitamin C Silver Ciao Tablets” on her own. Poor efficacy, 3 days ago fever, with dyspnea, taking antipyretic drugs, body temperature can temporarily drop. 1 day ago fever is obvious, body temperature up to 39 ℃, self-medication body temperature drop. She was admitted to the local hospital and was given antiviral treatment for one day (specific drugs are not known). On the morning of the 28th, he visited Shanxi Provincial People’s Hospital and checked the return of throat swab: influenza A (H1N1) virus nucleic acid was detected. He was diagnosed with influenza A (H1N1) and was transferred to the intensive care unit (ICU) of our hospital for further treatment. Admission examination: both lungs respiratory sounds low, both lungs bottom can be heard wet rhonchi, especially in the left lung.D-dimer: 895ng/mL.Chest CT shows: both lungs multilobar, multi-segmental patchy high-density shadow. Blood counts were significantly elevated. Biochemical series of cardiac enzymes were significantly elevated. Blood sedimentation increased. Blood gas analysis suggested hypoxemia. After admission, the patient was given oxygen therapy, antiviral, anti-infection, hepatoprotection and symptomatic supportive therapy. After admission, the patient’s condition further aggravated, intermittent irritating cough, occasionally coughing up white foamy sputum, sputum slightly with bright red blood, slightly tightness, body temperature up to 39.7 ℃, hypoxia further aggravated. Chest CT lung lesions significantly aggravated, the addition of methylprednisolone and strengthen the anti-infective treatment. On the fourth day, non-invasive ventilator-assisted respiration was performed to improve oxygen symptoms and strengthen anti-infection treatment. Temperature control was still unsatisfactory. On the 8th day of hospitalization, sputum culture was reported as Actinobacillus lupus, which was sensitive to amikacin and ciprofloxacin. According to the drug sensitivity, the anti-infective drugs were adjusted, and the chest physiotherapy was strengthened to promote sputum expulsion. On the 10th day of admission, the lung lesions were aggravated by chest CT, considering pulmonary sepsis, and Swo anti-infective drugs were added and sputum drainage was strengthened. On the 18th day of admission, cough and sputum decreased significantly, body temperature was normalized, and oxygen was replaced by oxygen mask. On the 23rd day of admission, the pharyngeal swab was negative for influenza virus nucleic acid, and the isolation was lifted. She was discharged on the 27th day.