Urticarial drug rash is a type of drug dermatitis, which can present with urticaria, itching and serum sickness-like symptoms. It can be caused by both hypersensitivity and non-hypersensitivity mechanisms, the former being most often caused by serum products, furazolidone, penicillin and beta-lactam antibiotics. In the latter case, aspirin and other non-steroidal anti-inflammatory drugs are the most common triggering drugs. Clinical manifestations are flushed, flaky windswept masses with more pronounced and prolonged itching, which may be accompanied by reactive elevation of peripheral blood leukocytes. It can also be accompanied by serum sickness-like symptoms such as fever, joint pain, lymph node swelling and even proteinuria. In severe cases, anaphylaxis can occur. In addition, it is recommended that patients with urticarial drug rash go to the hospital in time and follow the doctor’s instructions for treatment to avoid delaying the condition.