Hyperlipidemia refers to the plasma of one or more kinds of lipid substances higher than normal, including cholesterol, triglycerides, phospholipids and non-free fatty acids. Commonly used lipid-lowering drugs include simvastatin, ezetimibe, probucol, koratipine, fenofibrate, etc. It is recommended to use them under the guidance of a doctor, and their medication varies in different situations. Commonly used drugs for lowering blood lipids include statins (simvastatin), intestinal cholesterol inhibitors (ezetimibe, etc.), bile acid sequestrants (colestipol, etc.), fibrates (fenofibrate, etc.), and nicotinic acid (e.g., acipimox, etc.). Drugs such as Probucol, Mipomersen, and Lomitapide are also used in the treatment of hyperlipidemia. Different drugs have different indications, as well as different contraindications and adverse effects. Doctors will choose the most appropriate and effective drug for treatment based on the severity of the patient’s condition and the effectiveness of the treatment. In addition, for extremely severe hyperlipidemia, surgical treatment, such as liver transplantation, needs to be considered. It is recommended that patients with hyperlipidemia should follow the doctor’s instructions and not use drugs blindly on their own to avoid delaying their condition. In addition, daily dietary control and lifestyle improvement, such as eating less cholesterol-rich foods like egg yolks and animal offal, as well as proper exercise, are also conducive to the control of blood lipids.