Patchouli Zhengqi Shui is used internally orally, and the skin’s ability to absorb it is limited, the drug is generally not used externally to treat disease. There is no clear authoritative statement in the clinic as to whether or not applying Huo Xiang Zheng Qi Shui is effective for patients with urticaria. Patchouli Zhengqi Shui is composed of Cangzhu, Chenpi, Houpu, Angelica dahurica, Poria, Dabu Pi, and Shengbianxia, etc. It has the efficacy of relieving surface dampness (relieving the evils of the external senses and getting rid of dampness in the body), regulating qi and neutralizing the middle (regulating the qi of the spleen and stomach and making the functions of the spleen and stomach smooth). It can be used for colds and flu caused by external wind-cold, internal dampness stagnation (stagnation of dampness in the body due to overly cold diet) or summer dampness (the human body is susceptible to summer heat and dampness in summer), with symptoms such as headache, heaviness, chest and diaphragm constriction, distension of the epigastric region, vomiting and diarrhea, as well as gastrointestinal colds with the above mentioned manifestations. The drug may cause nausea, vomiting, skin rashes, itching, dizziness, flushing and other adverse reactions, and is contraindicated in patients who are allergic to the drug. The method of use of Ichthyspermum is internal oral administration, and the drug is generally not recommended for external use to treat the disease. Patients with urticaria are advised to go to a regular hospital, under the guidance of a professional physician to identify the treatment.