Cirrhosis is the ultimate end of the evolution of chronic liver injury in each, there should be a correct understanding of cirrhosis, on the one hand, we should recognize that once cirrhosis occurs, especially to decompensated cirrhosis can often cause life-threatening complications, so we should pay sufficient attention; on the other hand, we should recognize that from chronic hepatitis to cirrhosis there is a long process of liver fibrosis, we have sufficient time to prevent and We should not live in fear or even give up on ourselves, but there are still certain means to prevent and delay cirrhosis. The diagnosis of cirrhosis in the compensated stage is not easy, these patients often do not have typical clinical symptoms and signs, and even the laboratory tests of some patients are basically normal, we need a comprehensive examination to determine whether the patient has entered the stage of cirrhosis, such as a decrease in albumin level, leukocyte and platelet counts slightly below normal, imaging examinations (including ultrasound and CT, MRI, etc.) show that the liver surface is not These changes are often the manifestations of compensated cirrhosis, and when it comes to decompensated cirrhosis, there are usually complications of different degrees, such as primary peritonitis, hepatic encephalopathy, significant decline of white blood cells and red blood cells, hepatorenal syndrome, rupture and bleeding of esophageal and gastric fundic varices, etc. From the above, we can see that the increasing liver fibrosis is the inevitable way of cirrhosis formation. The fibrous tissue in the liver is composed of extracellular matrix (ECM), and these ECM include collagen, non-collagenous protein and proteoglycan composition, and it was previously thought that fibrosis in the liver is like the formation of scars after our skin is broken, which is static and unchanging. When ECM production is greater than degradation, liver fibrosis increases, and vice versa, liver fibrosis decreases. It is now recognized that stellate cells in the liver play a key role in the formation and degradation of ECM. A sustained inflammatory response in the liver can produce many inflammatory factors that can activate stellate cells, which can proliferate and produce cirrhosis, and the inflammatory response in the liver is often the result of the persistence of the etiology (persistent viral replication, alcohol or drugs). It follows that the key to preventing and delaying cirrhosis is to reduce liver fibrosis. How to reduce fibrosis in the liver? The first step is to remove the cause of liver damage, and for the viral hepatitis phase caused by type B and C it is necessary to provide aggressive, effective and continuous antiviral therapy, including interferon or nucleoside analogue therapy for hepatitis B and interferon combined with ribavirin for hepatitis C. Only the reduction of viral replication can reduce the virus, and also reduce the immunopathological damage against the virus, thus fundamentally eliminating the pathological basis of liver fibrosis. Secondly, aggressive hepatoprotective therapy, such as glycyrrhizin and other hepatoprotective drugs can reduce intrahepatic inflammation and protect hepatocytes, and herbal medicines have different degrees of anti-fibrotic effects. In addition, it is worth noting that the correct management of chronic hepatitis is a concept that should be strengthened in the diagnosis and treatment of liver disease today, the standardized management of doctors and self-management of patients, regular checkups are important links in the management of liver disease, only regular checkups can be found early in the best time of treatment when hepatitis, improve the efficacy of treatment, prevent and early detection of cirrhosis and thus early intervention, for patients with chronic hepatitis is well understood, but For chronic HBV carriers with normal liver function may be more difficult, mainly because their disease progresses more slowly and insidiously, especially farmers, patients with familial hepatitis B carriers and those with liver cancer, many of whom are middle-aged and wealthy, it is not uncommon to find life-threatening advanced cirrhosis or even liver cancer.