Many patients are afraid that they will gain weight or even get breast cancer or endometrial cancer if they use hormones. In fact, many of these fears are unnecessary and are even prejudices and misconceptions about hormone replacement therapy. Here we will vindicate hormone replacement therapy. Hormone replacement therapy induced breast cancer is still controversial Hormone replacement therapy (HRT) mostly refers to female hormones, especially estrogen replacement therapy, and its effect on breast cancer development is still debated, but it is certain that the risk of hormone replacement therapy causing breast cancer is small (less than 0.1%/year). Moreover, the risk of getting breast cancer is lower in people treated with estrogen alone than in the normal population. Only in the case of combined estrogen + progestin, certain progestins may have some effect on the breast, but there are data suggesting that natural or certain synthetic progestins (e.g., micronized progesterone and didrogestrel) may not increase the risk of developing breast cancer. In conclusion, breast cancer patients remain a contraindicated group for hormone replacement therapy, but if you are not a breast cancer patient, the likelihood of developing the disease is therefore very low as long as you use the medication under the guidance of a medical professional. It reduces the incidence of endometrial and colon cancer in menopausal women Hormone replacement therapy results in a lower incidence of endometrial hyperplasia and endometrial cancer in menopausal women than in the general population, and reduces the incidence of colon cancer. Estrogen alone does have adverse effects on the endometrium, but hormone replacement therapy is generally a combination of estrogen and progestin to protect the endometrium and reduce the risk of endometrial cancer. The prevention of colon cancer by estrogen may be related to its effect of reducing the production of secondary bile acids (which in high concentrations can be converted into substances with strong carcinogenic effects). Menopausal women are prone to obesity because their metabolism is reduced and their adipose tissue is not easily consumed. Hormone replacement therapy can adjust the lipid metabolism and put it in a balanced state, which not only has the effect of lowering blood lipids, but also can promote the normal distribution of fat, instead of just piling up on the stomach. The use of hormone replacement therapy in early menopause can reduce the risk of stroke and thrombosis The chance of stroke, thrombosis and embolism is very much related to the timing of the use of hormone therapy. Early menopausal women are at less risk of developing vascular embolic disease and other diseases than women in late menopause, so the earlier hormone replacement therapy is used, the greater the benefit and the less the risk. Scientists have researched and found the optimal time for hormone replacement therapy during menopause, also known as the “window of safety”. This “time window” is less than 60 years old and less than 10 years after menopause. It is safe to apply hormones continuously for 5 years during this period, not only to improve menopausal symptoms, but also to prevent stroke, thrombosis, embolism and Alzheimer’s disease. However, for patients who have been menopausal for more than 10 years and are older than 60 years old, hormone replacement therapy may do more harm than good, and a comprehensive risk assessment is needed to determine whether to use hormone replacement therapy at this time. Although hormone replacement therapy is good, it should not be “abused” In addition to resisting hormones, there is another extreme group of people who abuse hormones in order to “stay young forever”, which is definitely a misconception. It is important to pay attention to the word “replacement” in hormone replacement therapy, which means that only those who are deficient need external help to replace them, while those who are not deficient will only get into trouble if they use it indiscriminately. Excessive estrogen can upset the endocrine balance of the body, such as breast pain, abdominal soreness and a feeling of falling, and even increase the risk of endometrial cancer and breast cancer.