In multi-drug resistant tuberculosis, there can be serious consequences if not treated properly. First of all, it can lead to systemic spread of TB, which can result in the formation of TB lesions in the corresponding sites and organs. For example, the formation of bone tuberculosis can lead to fractures and paralysis in severe cases. When cerebral tuberculosis is present, this type belongs to patients with severe tuberculosis and can have serious complications and sequelae with a poor prognosis and a high mortality rate. Because multi-drug-resistant tuberculosis is not sensitive to multiple anti-tuberculosis drugs, patients with active multiplication of Mycobacterium tuberculosis, such patients are highly infectious, which can easily lead to the transmission and spread of tuberculosis, and is very dangerous for public safety and. For patients with multi-drug-resistant TB, if it is difficult to control the disease, it is easy to produce serious damage to the lungs, which can lead to respiratory failure in serious cases, affecting the patient’s quality of life or even life-threatening, etc. Patients have to take multiple anti-tuberculosis drugs for a long time, especially second-line anti-tuberculosis drugs, which increases the cost of patients and also increases the adverse effects of anti-tuberculosis drugs. Therefore, for multi-drug-resistant tuberculosis, we must guide the selection of effective anti-tuberculosis drugs for systemic treatment according to their drug sensitivity tests at an early stage to avoid serious complications and sequelae.