(Disclaimer: This article is for scientific use only, and the information in the following content has been processed to protect patient privacy.) Abstract: The patient had a history of viral hepatitis C for many years and presented to the clinic with symptoms of vomiting blood and black stool, and was diagnosed with upper gastrointestinal bleeding with viral hepatitis C, or hepatitis C, as a result of the examination. The occurrence of the disease may be related to the presence of a history of blood donation. After systematic treatment, the patient’s condition was controlled, the bleeding symptoms disappeared, and the prognosis was relatively good. Basic information】Female, 50 years old 【Disease type】Hepatitis C 【Visiting hospital】The First Hospital of China Medical University 【Visiting time】April 2015 【Treatment plan】Intravenous injection (posterior pituitary injection, glucose injection) + oral medication (sofosbuvir tablets, gecarevir peruntavir tablets) + endoscopic treatment (hemostatic clip to stop bleeding) 【Treatment cycle】Inpatient treatment for 2 days, home medication for 2 months 【Treatment effect】After treatment, the patient’s symptoms of vomiting blood and black stool disappeared and his condition was stable I. Initial interview When we first saw the patient, he was well developed, normal body shape, autonomous body position, self-expression, anemic face, and good mental status. The patient reported nausea in the early morning, followed by vomiting about 100 ml of fresh blood, and then repeatedly vomiting about 800 ml of dark red watery material three times, accompanied by sweating, dizziness, and weakness, and having two stools, initially normal-colored and later black dilute stools, and came to the hospital for a definite diagnosis. The patient was asked about the absence of abdominal pain, acid reflux and cough, but there was a history of blood donation and a 20-year history of viral hepatitis C without systematic treatment, as well as a habit of smoking and drinking alcohol, so the initial diagnosis of viral hepatitis C with upper gastrointestinal bleeding could be made, and further diagnosis was recommended. Subsequently, routine blood tests, fecal occult blood test and serum immunological examination were given. The results of routine blood tests indicated decreased hematocrit, positive fecal occult blood test and positive serum immunological test results indicated HCV, confirming the diagnosis of hepatitis C. After admission, the bleeding point was explored endoscopically, suggesting a ruptured esophagogastric fundic vein, and the bleeding was stopped by clamping with hemostatic clips. In addition, posterior pituitary injection and glucose injection drip were given for hemostasis and rehydration, and after the bleeding symptoms subsided, the patient was prescribed sofosbuvir tablets and gecarevir peruntavir tablets for antiviral treatment. After discharge, the patient was told to continue taking the medication for 2 months and that he needed to return to the hospital for a review after 2 months to clarify the effect of treatment. III. Treatment effect The patient’s bleeding symptoms disappeared and the hepatitis C condition was controlled after endoscopic treatment as well as drug therapy. After endoscopic treatment, the patient’s symptoms of vomiting blood and black stool improved, and with rehydration treatment, his physical condition stabilized, and he was rechecked with routine blood and stool occult blood test, and the hematocrit returned to normal, and the occult blood test result was negative. Two months after the antiviral treatment, the patient’s serum immunological examination was repeated, and the result indicated that the HCV antibody was negative, so the treatment effect was satisfactory, but regular review was still needed. I am sincerely happy for the patient that her symptoms are relieved and her health is gradually restored after treatment, and I remind her to pay attention to the following matters: 1.Pay attention to adequate rest, maintain regular rest and avoid straining, and also maintain a positive and optimistic state of mind to avoid stimulation leading to recurrence of the disease; 2.Patients should try to avoid eating greasy, spicy and cold food, and also To avoid eating too hard, high fiber content of food. Patients should avoid oily, spicy and cold foods in their diet, and avoid hard and fibrous foods. They should eat soft and easily digestible foods such as millet porridge and egg custard. V. Personal insights The general population should also be alert to the case of 50-year-old Aunt Zhang, who had a 20-year history of hepatitis C but was not treated regularly, leading to an aggravation of the disease and a coagulation disorder, which led to upper gastrointestinal bleeding. Hepatitis C is a disease that can be cured, but it is also an infectious disease that is usually transmitted through blood, so it is recommended that the general population, especially those with a history of blood donations and transfusions, should go to the hospital for regular physical examinations to clarify their health status, and should also go to the hospital in a timely manner if they develop uncomfortable symptoms to avoid delays.