With the development of the disease, some patients will feel very painful when pancreatic cancer develops to advanced stage. The clinical manifestations are as follows: 1. Obstruction symptoms: Patients may show difficulty in swallowing, i.e. it is very difficult to swallow things and cannot eat, in this case, patients may have liquid food. If the situation is more serious, they can only drink water or milk, etc. In this case, the patient may have to drink water or milk. In this case, a nutritional tube can be placed to enter the duodenum through the pylorus to solve the problem of eating, and an endoprosthesis can be placed in the esophagus and cardia to expand the stenosis according to the condition. 2. Local lymph node metastasis: for example, pain caused by retroperitoneal metastasis or hepatic metastasis, which is more painful to the patient. treatment.