The painful stage of advanced esophageal cancer is manifested as special difficulty in swallowing food, hoarseness, weakness, cancer invading surrounding organs and metastasis, jaundice and fluid accumulation in abdominal cavity, which will make patients with esophageal cancer feel painful at this time. The symptoms that can cause pain in late stage of esophageal cancer include difficulty in swallowing, vomiting, weight loss and pain, etc. 1. Difficulty in swallowing: As the advanced stage of esophageal cancer gradually progresses, the tumor will further become larger, resulting in more serious choking, which makes it difficult to swallow even a liquid diet; 2. Vomiting: After choking on diet, the patient will easily vomit out mucus, which will easily cause choking and pneumonia; 3. 5.Other: When the tumor metastasizes to other organs, pleural and abdominal effusion, mediastinal abscess, lung abscess and hemorrhage of aortic perforation may occur; when the tumor compresses the recurrent laryngeal nerve, it will produce hoarseness, bone metastasis will cause continuous bone pain, liver metastasis will cause jaundice and other liver function abnormalities, etc. When the tumor compresses the laryngeal nerve, it will produce hoarseness, bone metastasis will cause persistent bone pain, liver metastasis will cause jaundice and other liver abnormalities. For patients with advanced esophageal cancer, medical staff and family members should give more care and attention, and take symptomatic measures to reduce pain. If there is difficulty in swallowing, intra-enteral nutrition through indwelling gastric tube can be given, and intravenous nutrient solution can also be given to support treatment. In case of vomiting, metoclopramide can be given as prescribed by the doctor to stop vomiting, and analgesic drugs such as morphine can be given under the guidance of the doctor to stop pain during painful episodes. Try to improve the patient’s quality of life and reduce the patient’s pain.