Headache is not necessarily related to the novel coronavirus, but is associated with neurological disease if it is accompanied by headache and no other symptoms. Novel coronavirus infection is usually associated with upper respiratory tract infection symptoms such as fever, dry cough, and a variety of complications such as headache, fatigue, and muscle aches, which can lead to respiratory distress syndrome symptoms such as chest pain, chest tightness, and dyspnea. Headache is a common symptom of many viral infections, and fever or lack of oxygen can cause headache due to dilation of intracranial blood vessels. In addition, a variety of factors such as lack of sleep and emotional stress caused by viral infections can also lead to headache.