Risk factors for coronary heart disease include old age, male gender, family history of early-onset coronary heart disease, personal history of atherosclerotic disease, hypertension, smoking, increased total serum cholesterol or LDL cholesterol, decreased HDL cholesterol levels, diabetes, obesity, and lack of physical activity. Recent studies have also identified a number of newly emerging risk factors, including pro-inflammatory factors, new lipid risk factors, pro-coagulant factors, and hyperhomocysteine, that are associated with an increased risk of developing coronary heart disease. In addition, genetic polymorphisms and genetic abnormalities directly affect the regulation of lipoproteins, glucose and blood pressure. The risk of developing coronary heart disease rarely depends on a single risk factor, but in most cases is determined by the synergistic effect of two or more risk factors, and the combined risk of multiple risk factors interacting with each other is much higher than the sum of the effects of individual risk factors. Clinicians should pay attention to identify individuals at high risk for coronary heart disease, intervene in risk factors and detect coronary heart disease early. 1. age: men > 55 years, women > 65 years 2. gender: at any age in adulthood, the risk is higher in men than in women, but the risk increases significantly in women after menopause and gradually approaches that of men. 3.Family history of early-onset coronary heart disease: First-degree relatives such as parents or siblings who developed coronary heart disease or peripheral vascular disease before the age of 50 have a significantly higher relative risk of developing coronary heart disease than the general population. 4. Personal history of atherosclerotic disease: Patients who have had peripheral vascular disease, stroke or transient ischemic attack have an increased risk of developing coronary heart disease.