Parkinson’s disease is a common neurodegenerative disorder occurring in middle age and older. The main lesions are in the substantia nigra and striatal pathways, resulting in resting tremor, increased muscle tone, and bradykinesia due to decreased dopamine production. The disease occurs most often in middle-aged and older adults over the age of 50-60 years, but familial and juvenile Parson’s disease are also found in genetic typing. It is slightly more common in men than in women. The incidence rate is about 75-80% of all patients. 1, age aging Parkinson’s mainly occurs in the middle-aged and elderly people, the incidence of rare before the age of 40, suggesting that old age and the onset of related. It has been found that after the age of 30, the activity of nigrostriatal dopaminergic neurons, tyrosine oxidase and dopa decarboxylase, and the level of striatal dopamine transmitter gradually decrease with age. However, only a small number of elderly people suffer from this disease, indicating that physiological dopaminergic neuron metamorphosis is not enough to cause the disease, and aging is only a contributing factor to the development of this disease. 2.Environmental factors Epidemiological survey results found that there are regional differences in the prevalence of Parkinson’s disease, so it is suspected that there may be some toxic substances in the environment, damage to the neurons of the brain. 3.Genetic susceptibility In recent years, the Alα53THr mutation of the a common nucleolin gene has been found in patients with familial Parkinson’s disease. However, it has not been confirmed many times in the future. Family heredity medical doctors in long-term practice found that Parkinson’s disease seems to have a tendency to family aggregation, there are Parkinson’s disease patients in the family of their relatives the incidence rate is higher than the normal population. Parkinson’s Disease Classification and Clinical Differences Classification: Class I is the mildest, Class V is the most severe. Grade I: symptoms on one side, mild dysfunction. Grade II: symptoms in both limbs and trunk, normal postural response. Grade III: Mild postural dysfunction, self-care, loss of labor. Grade IV: Obvious postural dysfunction, loss of life and labor, can stand, can walk a little. Grade V: help to get up, limited to wheelchair life. Clinical differences: 1, in the early onset of the disease began to receive reasonable treatment of patients, the vast majority of patients can delay the development of the disease, the condition is relatively stable, life can basically take care of themselves. 2. Patients who receive treatment but interrupt it from time to time are mostly unable to control their condition well, and their condition will be repeated and aggravated to different degrees. 3, the development of late to start treatment patients, the condition is often very serious, the existing treatment means to improve the disease is also very limited, patients usually appear obvious disability. The four major symptoms of Parkinson’s disease: dyskinesia, tremor, tonus, postural reflexes Parkinson’s disease treatment medications are: levodopa, methyldopa, and resting. Dopamine agonists: bromocriptine, tamsulosin, pramipexole, etc. Beta-monoamine oxidase inhibitors (silagiline, etc.). Catechol-oxygen-site-methyltransferase (COMT) inhibitors. Anticholinergic hormone drugs: antan, scopolamine, kymagune, benzyltropine, etc. Amantadine, etc. Principles of medication ① Start a healthy search from a small dose, slowly increasing, try to achieve satisfactory results with smaller doses; ② Individualization of the treatment program, according to the patient’s age, the type of symptoms and degree of employment, drug prices and affordability and other choice of drugs; ③ should not blindly add drugs, should not suddenly stop taking drugs, need to take a lifetime; ④ PD medication is complex, in recent years, the introduction of adjuvant DR agonist drugs, MAO-B inhibitors, catechol-oxygen methyltransferase (COMT), etc., and compound dopa can enhance the efficacy of the combination to reduce the symptoms of fluctuations in the dose of compound dopa, the efficacy of the use of alone is not ideal, should weigh the pros and cons, the appropriate choice of joint medication. Parkinson’s disease diet 1, eat more cereals and vegetables and fruits. 2, eat more moderate amount of milk and beans. 3.Eat limited amount of meat.