Systemic lupus erythematosus (SLE) is an autoimmune-mediated, diffuse connective tissue disease with prominent manifestations of immune inflammation. It will be referred to as SLE. When you are diagnosed with SLE, in addition to following your doctor’s advice to start treatment, it is also very important for patients to manage themselves. There are several suggestions to help SLE patients. 1, SLE condition has mild, moderate and severe, very severe, you should find out from the competent doctor which category your disease belongs to and whether there is any organ involvement. 2, SLE patients need to check the most basic indicators for each review are blood routine, liver and kidney function, C-reactive protein, blood sedimentation, humoral immunity, and autoantibody quantification once every 3-6 months. If there is lung involvement, it is recommended to review the lung CT in 3-6 months. if there is kidney involvement, it is recommended to review the 24-hour urine protein quantification every month. 3.SLE patients with hormones and immunosuppressants are prone to increased risk of infection, so they need to pay attention to self-protection and not to go to crowded places during flu season. 4.Hormones are recommended to be taken at 8-9 am so that its side effects will be minimized. 5, to prepare a small book, record their own hormone dose, and the time of adjustment, such as the use of immunosuppressants (such as: cyclophosphamide, cyclosporine, etc.) need to write down the use of the beginning of the time and the time to adjust the dose, the current dose, which will help you in the follow-up, so that the competent doctor better design your individualized treatment.