We have been conducting AMH testing at our center for over two years now and currently find that it is indeed an excellent method of evaluating ovarian function with accurate and reliable results based on the results of our center’s tests, so the following article is forwarded to illustrate this point as well. If we want to find an ideal method to assess ovarian reserve function, AMH is the closest indicator available. It comes from the secretion of antral follicles and small follicles, so levels are stable during the cycle and can be monitored at any time; it is a more accurate predictor of ovarian response to stimulation and the number of eggs gained, useful for individualized ovulation planning; it predicts ovarian hypofunction earlier than other indicators, alerting you to address fertility issues earlier. Wow, it’s a great tool for ovarian function assessment. Ovarian function assessment – AMH Women’s fertility is closely related to their ovarian function, and nothing is more familiar to those undergoing IVF treatment than the assessment of ovarian function, and nothing is more worrying than ovarian hypofunction. In the medical field, age, hormone tests such as basal follicle stimulating hormone (FSH) and estrogen (E2), and ultrasound to assess the number of follicles in reserve are often used as comprehensive reference indicators to assess ovarian function, but in recent years, Anti-Müllerian hormone (AMH) has been used as a new indicator to assess ovarian function. What is AMH? AMH is a glycoprotein hormone, which is the only hormone marker produced by granulosa cells at the primary stage from primary follicles to sinus follicles, and is expressed at the highest level in the antral follicles and small sinus follicles (i.e., the reserve follicles). In adult women, AMH only originates from the ovaries and can be used as an indicator of ovarian function, to evaluate ovarian reserve function and predict the effect of ovulation promotion. The significance of AMH test 1. AMH to assess ovarian reserve function The main indicators commonly used to assess ovarian reserve are: age, basal FSH, E2 level, inhibin B, basal sinus follicle count (AFC), ovarian volume, ovarian stromal blood flow, etc., but the ability to assess ovarian reserve is not very satisfactory. In contrast, AMH levels showed a significant positive correlation with the number of early sinus follicles, which was more correlated than sinus follicle count, inhibin B and FSH, and thus more reflective of ovarian reserve function. It has been found that serum AMH levels maintain a relatively static level from 18 to 29 years of age and start to decline rapidly after 30 years of age, with serum concentrations at approximately 2 ng/ml at 37 years of age, while FSH concentrations do not change significantly from 29 to 37 years of age. Thus, AMH changes relatively early in the series of events of declining ovarian reserve. 2. AMH predicts IVF treatment outcome AMH testing is equally significant in predicting IVF treatment outcome. How to accurately predict the ovarian response to ovulation-promoting drugs in order to obtain the right number of high-quality eggs and reduce the occurrence of complications is the key to the success of the assisted conception technique. Currently, age and basal FSH levels are the main predictors routinely used at home and abroad, but these indicators are not completely accurate in predicting ovarian responsiveness and IVF outcomes, as people of the same age, basal FSH level and height and weight may have completely different egg counts and success rates. In a study on the correlation between AMH and in vitro fertilization (IVF), blood AMH was found to be a more accurate predictor of ovulation cycle cancellation rates and egg production than FSH and E2 on day 2 of menstruation, and AMH levels can predict ovarian responsiveness and identify women at risk for ovarian hyperstimulation syndrome. For example, high levels of AMH indicate risk of ovarian hyperstimulation and low doses of gonadotropins should be used, while low levels of AMH indicate low ovarian response and higher doses of ovulation stimulating drugs should be used. It is generally accepted that when AMH is less than 0.5 to 1.1 ng/ml indicates diminished ovarian reserve function. AMH can help us to choose the appropriate individualized treatment, thus enhancing the effectiveness and safety of in vitro fertilization and improving the success rate of IVF. Most scholars believe that AMH can only predict the number of eggs gained, but it does not correlate with the final pregnancy outcome and cannot accurately predict IVF outcome. AMH is secreted by the granulosa cells of antral follicles and small sinus follicles <4mm in diameter, so AMH is not affected by the menstrual cycle or medications, and is stable at any time. It generates accurate and reliable stable results to assess ovarian reserve capacity. This shows that AMH test is indeed a good tool for ovarian function assessment! The reference value of AMH: 0.24-11.78 ng/ml for 20-40 years old, 0.00-1.22 ng/ml for 41-50 years old, generally greater than 4 ng/ml is considered normal. when AMH decreases, it means that the ovaries are aging, which means that female fertility is declining. However, AMH cannot predict the future decline of ovarian function. It is recommended that if you have a tendency to have a low AMH test, it is best to plan for fertility early to avoid delaying the best time to have children!