What is the difference between rheumatoid arthritis and osteoarthritis? 1, the pathogenesis is different: degenerative changes; autoimmune disease. 2, the pathological changes are different: degenerative changes of cartilage, and osteophytes; synovial lesions caused by bone destruction. 3, age of onset: old age; 40-50 years old. 4, the most commonly affected joints: distal interphalangeal joints, weight-bearing joints; metacarpophalangeal joints, wrist joints, proximal interphalangeal joints. 5.Different effects on the whole body: mostly limited to bones, joints, and periphery; in addition to joints, it can accumulate several organs. 6.Laboratory tests are different: no specific serological change indicators; multiple autoantibodies. 7. Different genetics: no significant correlation with human leukocyte antigen; HLA-DR4 has some correlation. 8, different medication and treatment response: mainly NSAIDs; anti-rheumatic drugs to improve the condition, together with NSAIDs.