Recently, the Department of Otolaryngology-Head and Neck Surgery was the first in the world to successfully complete four new procedures of pharyngeal balloon dilation for refractory secretory otitis media caused by radiotherapy for nasopharyngeal carcinoma. Secretory otitis media is one of the common, and quite problematic, long-term complications after radiotherapy for nasopharyngeal carcinoma. The reason for this is that high doses of radiotherapy damage the eustachian tube, the only external route to the middle ear; although some patients can be solved by middle ear tube placement for ventilation, some patients still remain untreated and in pain for a long time. For many years, the otolaryngology community did not have a solution to this problem. In recent years, German scholars have developed a specialized eustachian tube balloon to treat the dysfunction of the eustachian tube. This technique is based on the development of modern material science and has achieved good results by introducing a narrow eustachian tube through a slim catheter and then microdilating it with a balloon to avoid damaging the important tissues around the eustachian tube. However, for patients with refractory secretory otitis media caused by radiotherapy for nasopharyngeal carcinoma, surgery is risky because of the large damage to the eustachian tube caused by high-dose radiotherapy and the brittle tissues, and because there are few patients with nasopharyngeal carcinoma abroad, treatment for such patients has not been carried out abroad. Our department has taken the lead in applying this new technology to refractory secretory otitis media caused by radiotherapy of nasopharyngeal carcinoma internationally, and has done 4 cases with remarkable short-term efficacy, and is doing long-term follow-up observation.