Twenty-year-old man injected about two months estrogen-progestin total of four injections, resulting in breast development, impotence, usually related to the adverse reaction to the drug, no treatment in a timely manner to stop the drug, the majority of patients can be restored. Long-term injection of estrogen medicine may lead to increased estrogen levels and decreased androgen levels. In this case, the abnormal breast development and impotence, is an adverse drug reaction, usually without special treatment, stop using the drug, the body’s estrogen level will gradually decline, androgen levels will gradually rise, the symptoms will slowly get better, usually without special treatment. When using estrogen drugs, men should know that if they are allergic to the ingredients of the drug, or currently have an allergic reaction, it is not recommended to use. If endocrine disruption occurs during the use of the drug, resulting in a decrease in androgen levels, it is necessary to stop using it in a timely manner. If you need to use estrogenic drugs, it is recommended to do so under the guidance of a professional physician, and not without authorization, so as not to aggravate the discomfort.