When someone feels distorted vision, smaller vision or darker shadows in the center, it is usually due to macular disease. What are the macular diseases that can cause these symptoms? Macular fissure: Macular fissure is a defect of the whole layer of the retinal neuroepithelium in the macula. It is common in the elderly, eye trauma, high myopia, etc. Macular fissure in highly myopic eyes is prone to retinal detachment. Macular fissure can be divided into 4 stages, early can have visual deformation, treatment can be surgical closure of the fissure, can effectively preserve vision, if not treated, vision usually to 0.1 or below. Macular pre-membrane: Macular pre-membrane refers to the pre retinal proliferative membrane occurring in the macula, there is a thin or thick white membrane on the macular surface, the macular vessels are distorted, the local retina has radial stripes, the upper and lower vascular arch is straightened and close, the retina can have edema, punctate hemorrhage, as well as macular cystic degeneration, pseudopore formation, etc. Surgical debridement is the only treatment method. Mesoplasia: Central plasmacytoid chorioretinopathy is referred to as “mesoplasia”. It is usually seen in young and middle-aged men, with recurrent episodes of blurred vision, central vision loss, gaze darkening, visual distortion, discoloration, and after recurrent episodes, grayish-yellow hard exudate, pigment loss and pigment freeing. Treatment can be laser or drug therapy. Mesophoria: This is an isolated exudative chorioretinopathy occurring in the macula with subretinal neovascularization and hemorrhage. Due to the leakage, hemorrhage, and mechanization of neovascularization, scarring eventually forms, causing permanent damage to central vision. Treatment is usually PDT in the active phase. Age-related macular degeneration: Age-related macular degeneration is mainly manifested by the decreased phagocytic digestion ability of retinal pigment epithelial cells to the outer segment of optic cells disc membrane, as a result, the residual vesicles of the disc membrane that have not been completely digested are retained in the basal cell protoplasm and discharged to the extracellular area, deposited in Bruch’s membrane, forming vitreous warts. Macular degeneration is a chronic eye disease, which can cause a rapid loss of central vision. The main pathological changes are proliferation, atrophy and detachment of retinal pigment epithelium in the macula, and the most frightening is the appearance of choroidal neovascular membrane under the retina, these unhealthy vascular membranes are prone to rupture, bleeding and scar formation. Age-related macular degeneration is divided into two types: dry and wet, and the treatment includes surgery, PDT and vitreous cavity injection.