HFMD and pharyngitis are initially distinguished from each other mainly by the site of occurrence and the patient’s clinical manifestations. HFMD may present with a rash or herpes manifestations on the skin mucosa of the hands, feet, mouth, buttocks, etc., whereas the mucosal damage of pharyngitis is most often seen on the pharyngeal palatal arch, soft palate, and tonsils. Rashes, herpes or ulcers are often seen on the hands, feet, mouth and buttocks of patients in the early stages of HFMD. Compared to pharyngitis, which has a wider range of damaged areas, in addition to the skin changes, some patients may also present with lethargy, vomiting, headache, and other manifestations of the period of neurological involvement. Pharyngitis mainly involves the pharyngeal and palatal arches, soft palate and tonsils and other parts of the oral cavity, and patients often experience symptoms such as sore throat, cough and loss of appetite. If patients experience the above symptoms, it is recommended that they go to the hospital as soon as possible and actively cooperate with the doctor for treatment.