Patients with advanced tuberculosis can be contagious. Patients with sputum-positive tuberculosis are the main source of infection. Patients with advanced tuberculosis can appear sputum-positive, so they can be contagious and should be properly isolated from children, the elderly and people with low immune function, such as diabetic patients, tumor patients and patients using chemotherapy drugs. Also, patients diagnosed with TB should be treated aggressively to reduce contagiousness. The common drugs include isoniazid, rifampin, rifapentine, pyrazinamide, streptomycin, ethambutol, etimesine, levofloxacin, etc. The principles of application are early, appropriate dosage, combination, whole course, and regularity.