The most likely manifestations: 1. Do you have pain at night? If you keep waking up with pain in your sleep recently, you should pay high attention to it; 2. Is there a part of your body that has been in constant pain recently and shows a tendency to get progressively worse? If so, please seek medical attention promptly. 3. Has a part of the body recently become swollen, with a mass that grows faster? If these masses are combined with local skin redness, swelling, and pain, they are most likely due to inflammation; if these masses are not accompanied by obvious pain, they should be given high priority; 4. Is there any recent manifestation of difficulty in walking on the lower extremities, difficulty in moving the upper extremities, or restriction of movement of the cervical and lumbar spine? If these movement restrictions affect your normal life, please seek medical attention promptly; 5. Is there any fracture during lifting, carrying, riding the bus or accidentally falling? Unless you are over 80 years old or have severe osteoporosis, you should go to hospital for further examination; Factors most likely to get bone cancer: 1. If yes, the chance of bone cancer will be significantly increased. 2. Is it accompanied by obvious weight loss? If the diet is normal but the weight is significantly reduced, please go to the hospital for medical consultation in time; 3. Are you frequently exposed to radioactive substances, chemicals, industrial and agricultural pollutants such as heavy metals, toxic gases, etc.? If yes, please go to the hospital for regular medical check-up; 4. Is there more than one cancer patient of the same kind in your family? Such as breast cancer, cervical cancer, esophageal cancer, liver cancer, etc. If yes, you should also do your own physical examination regularly; 5.Is there any missing or extra part of your bones found in imaging examination? If yes, please go to the professional department for confirmation or examination in time. If you find yourself with more than 2 of the possible manifestations and more than 3 of the possible factors, please seek medical attention in time to rule out whether you have bone cancer or other malignant tumors. The above opinions are only our own clinical summary without data analysis, which are for reference only and do not have any authority.