With the development of IVF technology, birth defects in the offspring have become a concern, and a 2002 Australian study found that the rate of birth defects in babies born with this technique was two times higher than in natural pregnancies, mainly in the form of increased incidence of neural tube abnormalities and large vessel displacements. European and American countries found a significantly higher incidence of low and very low birth weight, abnormal neurological development and congenital malformations in their offspring. IVF technology has far-reaching implications for fetal epigenetic alterations. In particular, the single sperm intracytoplasmic injection technique may even cause intergenerational inheritance of disease by affecting the gonads of the offspring Most infertile couples are not absolutely infertile, but are relatively infertile in a low-fertility population, with roughly 80% to 90% of the population being able to obtain their own offspring with general treatment. Only 5% to 10% of the population needs to resort to IVF technology. In view of the adverse effects of assisted reproduction techniques on the offspring, it is advisable for infertile couples to choose natural pregnancy as far as possible, as natural pregnancy conforms to the laws of physiology and nature, without the effects of in vitro culture, and with minimal impact on the offspring, and is the best choice. Only couples who are unable to conceive naturally can choose assisted reproductive technology to have the next generation. Do not choose IVF technology blindly, otherwise you will only temporarily satisfy your dream of fertility and regret it for the rest of your life.