Tumors of pathologic mesenchymal origin generally refer to gastrointestinal mesenchymal tumors. Tumors of pathologic mesenchymal origin generally refer to mesenchymal tumors, which are called gastrointestinal mesenchymal tumors because they generally originate as mesenchymal tumors in the wall of the gastrointestinal tract. Patients with gastrointestinal mesenchymal tumors may present with vomiting blood and black stools, abdominal masses, and abdominal pain and distension. The most common sites for this disease are the stomach and small intestine, but it can also occur outside the gastrointestinal tract and can turn from benign to malignant. Patients with these symptoms should undergo stool examination, abdominal ultrasound, magnetic resonance imaging, genetic testing, and pathologic biopsy to make a definitive diagnosis. Patients with tumors of interstitial origin of pathology should actively seek medical treatment, do not delay the condition, do not self-medicate to avoid adverse results, and follow the standard treatment under the guidance of physician’s interview.