Betalactam is a commonly used beta-blocker, and sudden discontinuation of the drug by patients can lead to fluctuations in blood pressure and heart rate, and even threaten patients’ lives. Betalac has anti-hypertensive and anti-arrhythmic effects, which can improve myocardial remodeling and prevent cardiovascular disease. If the patient has good tolerance in clinical drug therapy, no adjustment of the drug is needed and it should be taken consistently for a long time. If patients with coronary artery disease suddenly discontinue betalactam, a sympathomimetic reaction will occur, leading to increased myocardial oxygen consumption, reflexive increase in heart rate, and even inducing angina pectoris leading to sudden death. Once the physician agrees to discontinue betalactam, a gradual dose reduction strategy should be adopted, with the discontinuation process lasting at least 2 weeks, with the dose being reduced by half every 2-3 days and the minimum dose being taken for 4 days before discontinuation. In conclusion, patients should respond to their physicians promptly if they experience any discomfort during the Betalac dose reduction process to avoid serious consequences.