It is necessary to drink alcohol after 48 hours after taking roxithromycin, and be careful to drink in small amounts and not excessively. Roxithromycin is a new generation of macrolide antibiotics, its antibacterial activity and antibacterial spectrum is similar to erythromycin, it can have good antibacterial effect on Staphylococcus aureus and Streptococcus, Mycoplasma, Chlamydia, Legionella, Haemophilus influenzae, etc.. Roxithromycin is mainly metabolized in the liver, with a blood elimination half-life of 8.4-15.5 hours, and repeatedly enters the enterohepatic circulation. And the detoxification of alcohol is also in the liver, which is easily aggravated after drinking alcohol. Therefore, after taking roxithromycin, patients are advised to drink alcohol after 48 hours. Since some of the roxithromycin may still remain in the patient’s body at this time, the patient should also be careful to drink alcohol in small amounts in order to avoid damage to the liver. During the period of taking roxithromycin, patients are advised to stop drinking and smoking, to eat a light and digestible diet, to avoid spicy and stimulating foods, to drink warm water, to eat more fresh fruits and vegetables, and to ensure sufficient rest. In addition, hepatic insufficiency and pregnant and lactating women need to use roxithromycin with caution, and liver function should be monitored regularly during long-term use.