At the end of October 2015, Master Yao, who was over 80 years old, came to the Hepatobiliary Surgery Department of the First Central Hospital of Tianjin for treatment of yellow skin staining and fever for nearly half a month. The patient’s general condition was very poor when he first arrived at the hospital, with a weight loss of 5 kg, dark yellow skin and eyes all over his body, and a high serum total bilirubin of more than 200 in laboratory tests, 10 times higher than the normal value, with severely impaired liver function. The patient was considered to have biliary obstruction and biliary tract infection due to bile duct cancer after detailed laboratory examinations. The doctor carefully analyzed his condition and decided to perform radiofrequency ablation combined with stent implantation for bile duct cancer via endoscopy, considering the patient’s advanced age, previous cardiovascular and cerebrovascular diseases and poor general condition, which made surgical treatment more risky. The treatment was successfully completed under local anesthesia and took 40 minutes. The yellow color of his skin faded rapidly and his diet returned to normal. In fact, malignant obstructive jaundice caused by malignant cholangiocarcinoma or periampullary cancer like Master Yao is very common in clinical practice. The symptoms are hidden in the early stage of the disease, and most patients have already developed to the middle and late stage when they visit the doctor, with obvious jaundice and serious impairment of liver function, and some have lost the opportunity of surgery. Doctors can only relieve obstructive jaundice by interventional treatment, percutaneous biliary drainage, and endoprosthesis implantation, but interventional treatment only drains the bile duct, without treating the tumor, and is only a palliative treatment. If the tumor is not controlled, the infiltrative growth can easily lead to reocclusion of the stent. Intraluminal radiofrequency ablation therapy solves this problem. Radiofrequency ablation therapy is a minimally invasive procedure, the principle of which is to use electromagnetic waves of certain frequencies to destroy the cancerous tissues in the organism for treatment purpose. Radiofrequency ablation catheter is the latest technology invented by Habib, a famous professor of Imperial College of Science and Technology, for tumors in the luminal tract, which was approved by SFDA in China in 2012 for the treatment of malignant biliary tract obstruction. The advantage of this technology is that without damaging the normal bile ducts, it causes coagulation and necrosis of the tumor in the lumen and hinders the growth and infiltration of the tumor; at the same time, it implants a stent to keep the bile ducts open for a long time, which not only relieves the patient’s pain but also prolongs the survival time. The earliest patient who received this treatment in our department has survived for more than 18 months. This treatment has brought hope to patients with advanced tumors that are inoperable or physically unable to undergo surgery, and has not only greatly prolonged their lives but also allowed them to enjoy a quality of life.