1, chronic bacterial prostatitis pathogenic factors are also mainly pathogenic infections, but the body is more resistant or/and pathogen virulence is weak, to retrograde infection, the pathogens are mainly Staphylococcus spp, followed by Escherichia coli, rod-shaped bacilli and enterococci spp. Prostate stones and urinary reflux may be important reasons for the persistence of pathogens and recurrence of infection. 2, chronic non-bacterial prostatitis The etiology is very complex and its main cause may be the combined effect of pathogenic infection, inflammation and abnormal pelvic floor neuromuscular activity and immune abnormalities. (1) Pathogenic infections In this type of patient, although routine bacterial examination fails to isolate the pathogen, it may still be associated with some specific pathogens: such as anaerobic bacteria, L-type Aspergillus, nanobacteria, or Chlamydia trachomatis, mycoplasma, and other infections. Some studies have shown that the local prokaryotic DNA detection rate for this type of patient can be as high as 77%; some clinical “aseptic” prostatitis, which is predominantly chronic inflammation, recurrent or aggravated, may be associated with these pathogens. The other pathogens such as parasites, fungi, viruses, trichomonas, and Mycobacterium tuberculosis may also be important causative factors for this type, but there is a lack of reliable evidence and there is no uniform opinion yet. Many patients with prostatitis have a variety of urodynamic changes, such as reduced urinary flow rate, functional urinary tract obstruction, and dysfunction of the detrusor-urethral sphincter synergy. These functional abnormalities may only be a clinical phenomenon, and their nature may be related to various underlying pathogenic factors. For example, anxiety, depression, hypochondria, hysteria, and even suicidal tendencies. These changes in mental and psychological factors can cause plant nerve dysfunction, resulting in posterior urethral neuromuscular dysfunction, leading to pain in the pelvic region and dysfunctional urination; or cause changes in the function of the hypothalamic-pituitary-gonadal axis and affect sexual function, further aggravating the symptoms, and eliminating mental tension can lead to symptom relief or healing. However, it is unclear whether the psychosomatic changes are the direct cause or secondary manifestations. (4) Neuroendocrine factors Patients with prostate pain are often prone to fluctuations in heart rate and blood pressure, indicating that they may be related to autonomic responses. Their pain has the characteristics of visceral organ pain. Local pathological stimulation of the prostate and urethra triggers spinal reflexes through the afferent nerves of the prostate, activates astrocytes in the lumbar and sacral medulla, nerve impulses send out impulses through the genitofemoral and ilioinguinal nerves, and sympathetic nerve endings release norepinephrine, prostaglandins, calcitonin gene-related peptides, substance P, etc., causing vesicourethral dysfunction, and This leads to abnormal activity of the perineum and pelvic floor muscles and persistent pain and involvement pain in the corresponding areas other than the prostate. (5) Abnormal immune response Recent studies have shown that immune factors play a very important role in the development and evolution of type III prostatitis. Changes in the levels of certain cytokines, such as IL-2, IL-6, IL-8, IL-10, TNF-α, and MCP-1, can occur in the prostatic fluid and/or seminal plasma and/or tissues and/or blood of patients, and IL 10 levels are positively correlated with the pain symptoms in patients with type III prostatitis, and the application of immunosuppressive therapy has some effect. (6) Oxidative stress theory Under normal circumstances, the production, utilization and removal of oxygen free radicals in the body is in a dynamic balance. Prostatitis patients with excessive production of oxygen free radicals or/and the role of the free radical scavenging system is relatively reduced, thus reducing the body’s ability to respond to oxidative stress, oxidative stress products or/and by-products increase, may also be one of the pathogenesis. (7) Pelvic related disease factors Some patients with prostatitis are often accompanied by dilated venous plexus in the peripheral zone of the prostate, hemorrhoids, varicose veins of the spermatic cord, etc., suggesting that the symptoms of some patients with chronic prostatitis may be related to pelvic venous congestion and blood stagnation, which may also be one of the causes of prolonged treatment.