Calculate the dose of carboplatin by the area under the curve (AUC) and creatinine clearance: according to the Calvert formula. Carboplatin dose (mg) = set AUC (mg/ml/min) × [creatinine clearance (ml/min) + 25] AUC (mg/ml/min) taken: 5 to 7, often 5. Endogenous creatinine clearance is calculated using the Cockcroft formula: based on sex, age, body weight, and serum creatinine Male Ccr = [(140 – age) × Body weight (kg)]/[0.818×Scr (μmol/L)] or Ccr=(140-age)×body weight (kg)/72×Scr (mg/dl) Female Ccr is calculated according to male results×0.85 Note: Ccr (endogenous creatinine clearance) Scr (blood creatinine) The calculation of Ccr is referred to Baidu encyclopedia and internal medicine.