What is pharmacologic oophorectomy (or ovarian debulking)? Endocrine therapy is an important part of breast cancer treatment, which presupposes a positive estrogen receptor (ER) or progesterone receptor (PR), preferably both, for better results. Ovarian debulking is an important tool of endocrine therapy, mainly for premenopausal cases, but many patients have difficulty in undergoing traditional surgery or laparoscopic surgery and lose their ovaries permanently. Ovarian debulking was partially performed by radiation therapy in the past, which has been largely eliminated, and today most patients prefer pharmacological oophorectomy, which has the advantage that ovarian function can be restored after stopping the drug. Currently, these drugs are commonly used to inhibit the secretion of luteinizing hormone and follicle stimulating hormone by the anterior pituitary gland, and to inhibit the secretion of estrogen by the ovaries. For example: Norelide, 3.6 mg , subcutaneous injection, every 28 days for two years. Side effects include hot flashes, loss of libido, mild headache, nausea, etc., which can be tolerated.