Ordinary people can’t distinguish lipoma and liposarcoma by themselves, professional doctors can distinguish the two by the growth location, shape, texture and so on, but can’t accurately identify them, and pathological examination is needed to confirm the diagnosis. 1. Growth location: Lipoma is a benign tumor, which usually grows on the surface of the skin of arm, shoulder and back, etc. Liposarcoma is a malignant tumor, while liposarcoma is a malignant tumor. Liposarcoma is a malignant tumor, which grows in the body or thighs. 2. Appearance: Lipoma is mostly round, which can be big or small, and there are several cases of growing together and single. Liposarcoma is a combination of several small packets that are piled up into various shapes, such as small rounds, and liquid will appear inside when cut open. 3. Texture: when touching, liposarcoma has a peripheral membrane, and the boundary is clear and smooth when touching. On the other hand, the boundary of liposarcoma is not clear, and it may feel adherent to the surrounding tissues. 4. Pathological examination: the section of liposarcoma is mostly yellowish, and the tumor is wrapped by a thin layer of fibrous membrane with mature fat leaflets, the size and morphology of fat cells are consistent, and there are trabeculae inside to separate the fat leaflets, and there are branching fibrous tissues and capillaries between the leaflets. Liposarcoma tumors are mostly lobulated and nodular, with intermittent envelope visible, largely yellow or grayish-white, with delicate cut surface, resembling lipoma in appearance, but harder in texture than lipoma, and its cut surface is dark red due to hemorrhage and blood vessels, and mucus components can be seen in about half of the liposarcomas. Ordinary people can not diagnose the disease by themselves, lipoma and liposarcoma diagnosis needs to go to the hospital for pathological examination, after diagnosis, we should follow the doctor’s instructions for scientific treatment.