There are three types of preoperative puncture of breast masses, each with its own advantages and disadvantages, and their techniques, which are analyzed as follows: 1.Fine Needle Aspiration Biopsy (FNAB), fine needle aspiration biopsy Advantages: the chance of needle recurrence is 0.005 %, no statistical basis; Disadvantages: the amount of tissue is not enough to perform immunohistochemistry. 2. Core Needle Biopsy (CNB) with empty needle aspiration biopsy Advantages: sufficient amount of tissue for immunohistochemical examination; ER and PR match rate >90% Disadvantages: 22% needle tract implantation; however, CNB does not affect local recurrence after breast conservation + radiotherapy after aspiration; 3-4% false negatives Tips: 1. The needle tract is as vertical as possible; 2. 4-6 tissues are taken; 4 tissues, 14 Gauge (1.6284mm), 95% confirm the diagnosis, 2-3% do not wear positive cells 3. Check the specimen worn: the sinker is glandular, floating is fat 4. If the puncture is a calcified foci, it must be photographed and mark the original lesion site, and firmly follow up to avoid causing histological underestimation (52% of the puncture result is DCIS) If the puncture results in infiltrative carcinoma (52%); 5. 3.Mamotone Advantages: tumor epithelium is less likely because its needle set does not repeatedly enter and exit; its negative pressure can suck the mass closer and avoid air entering the residual cavity resulting in unclear puncture field; Disadvantages: thick needle, cutting a large number of cuts will lead to increased contact between tumor cells and blood In summary, various punctures have advantages and disadvantages, and CNB can be given priority in terms of selection.