Chronic urticaria is usually recurrent and long-lasting, with episodes of scattered erythematous lesions all over the body, accompanied by significant itching and other discomfort. There is no cure for chronic urticaria, so patients generally need long-term intermittent medication, and active treatment can bring the condition under control and allow them to return to normal life as much as possible. The etiology of chronic urticaria is more complex and most of them are difficult to clarify. They are affected by various exogenous and endogenous factors, the former including physical stimulation, food, drugs, etc., which are mostly temporary, and the latter including chronic occult infection, mental stress, etc., which are mostly persistent. Therefore, in the process of controlling symptoms, many drugs need to be taken for a long time and then slowly reduced. Patients should keep an eye out for suspected onset factors in their lives and try to avoid them, which can effectively reduce the number of attacks. The basic treatment of chronic urticaria requires the use of antihistamines such as loratadine, desloratadine, and cetirizine, etc. Most patients can have good symptom control with one drug. When it is difficult to control or the symptoms are particularly severe, treatment with hormones or immunosuppressive drugs can be applied under the guidance of a doctor. After the symptoms are controlled and maintained for a period of time, then consider reducing or stopping the medication. Topical medications can be used at the same time, usually stove glycolic lotion is chosen, and compound camphor cream or dermatol cream can be applied to relieve symptoms when significant itching occurs.