Otitis media with yellow water is mostly seen in suppurative otitis media and middle ear cholesteatoma, which need to go to the hospital for symptomatic anti-inflammatory treatment. For acute purulent otitis media treatment is mainly anti-inflammatory, first of all, we should clean up the purulent secretions in the external auditory canal, keep the external auditory canal clean, and then carry out levofloxacin ear drops ear bath treatment. At the same time with oral or intravenous antibiotics, generally preferred penicillin or cephalosporin antibiotics. If acute otitis media is not treated in time, it will gradually evolve into chronic otitis media. If the ear just has simple symptoms of yellow water, the treatment is still systemic and local antibiotic treatment. If there are granulations, cholesteatomas or polyps, or if the dry ear cannot be obtained for a long time through standardized conservative treatment, we should consider performing relevant surgical treatments, such as mastoidectomy and tympanoplasty, under the premise of meeting the indications for surgery. It is recommended that the patient should go to the hospital in time, after the systematic examination to clarify the diagnosis and condition, and follow the doctor’s instructions to standardize the use of medication and treatment.