Recently, the Department of Cardiac Surgery admitted a six-year-old boy from rural areas, suffering from congenital heart disease arteriovenous ductus arteriosus, admitted to the hospital for examination: the child has hepatitis C, we feel very puzzled, hepatitis C is mainly transmitted through blood and drug use, the child is very young, neither trauma surgery transfusion history, and no history of drug use, hepatitis C from where? While congenital heart disease has been cured at a cost of $10,000, hepatitis C is difficult to cure at the cost of modern medical conditions, and causes lifelong regrets. Since the discovery of the ABO blood group in 1900 and the creation of blood preservative in 1916, transfusion medicine has developed rapidly, and blood transfusions have saved the lives of countless patients who have lost blood (trauma, surgery), making a great contribution to human civilization. However, some people mystify blood, even some doctors believe that blood transfusion can strengthen the body’s resistance and have a nutritional effect; multiple transfusions can stimulate their own bone marrow to produce blood; some people also want to transfuse 400 blood to patients who do not bleed much during surgery, in order to keep the patient “safe”. Blood transfusion has only benefits and no harm, or more benefits and less harm. These ideas are unscientific and run counter to the modern concept of blood transfusion. In fact, the human blood system has a strong self-regulatory function, and the normal bone marrow hematopoietic system is abnormally active, and mild anemia can be corrected quickly. Although the plasma of whole blood contains albumin, immunoglobulin, and many kinds of antibodies, the content is limited and does not play a role in strengthening the body’s resistance. Generally speaking, the main way to increase nutrition is to take the appropriate food by mouth or to use more scientific extra-gastrointestinal nutrition therapy, such as intravenous injection of compounded amino acids and fatty milk. Experimental evidence shows that blood transfusion not only fails to stimulate hematopoiesis, but also inhibits its own hematopoietic function. Allogeneic blood transfusion is equivalent to allogeneic (cell) transplantation, even if the blood type (ABO) is the same, the transfusion is actually allogeneic blood, because the human blood group system is very complex, in addition to ABO blood group, there are many other subtypes, the current blood transfusion is generally done only ABO examination, some people observed that about 5% of the patients in the transfusion occurred in varying degrees of transfusion reaction, 1% of the patients occurred in serious transfusion reaction, and even life-threatening. Patients who have had multiple transfusions of whole blood have difficulty with subsequent bone marrow transplants or other organ transplants. At present, the maximum activity of leukocytes in bank blood preservation is not more than 8 hours, and platelets lose all their activity in 24 hours. Therefore, while transfusing bank blood, harmful substances such as cell debris, sodium citrate, potassium and ammonia ions are also input, which not only increase the metabolic burden of patients, but also increase the heart burden of patients. Blood transfusion is one of the main ways of transmission of hepatitis B, hepatitis C, syphilis, and AIDS, and such diseases transmitted by blood transfusion are not uncommon. Currently, 90% of post-transfusion hepatitis C eye infections are hepatitis C. Compared to hepatitis B, hepatitis C is more prone to chronic cirrhosis and a high percentage of liver cancer. In today’s medical world, there is a lack of effective treatment for these viral diseases, and they do not have the same curative effect as prediabetes, which can be treated surgically to become healthy and normal. Blood transfusions can both treat and spread the disease, and even bring very serious consequences. So, is it possible to have heart surgery without blood transfusion? With the increasing development and maturity of cardiac surgery technology, extracorporeal circulation intracardiac surgery without blood transfusion has become a reality. In recent years, 48 cases of heart patients have been achieved without blood transfusion, and none of them died or had complications, which fundamentally avoided blood transmission of disease. Therefore, when each doctor decides to give a patient a blood transfusion, he or she should take the patient’s vital interests as the starting point, so as to achieve the principle of transfusion only when blood must be transfused, less if it can be transfused, and better if it is not transfused. For those patients who do not have clear signs of blood transfusion, doctors must not accommodate the ignorant requests of patients and their families, and transfuse the “human blood” or “relationship blood”. Blood transfusion should also be transfused from regular blood stations.