Stony Bone Disease is also known as marble bone, primary brittle bone sclerosis, sclerosing proliferative bone disease and chalky bone. It is a rare disorder of bone development. It was first discovered by Albers-Schonberg (1904) and is also known as Albers-Schonberg disease. The disease is characterized by the persistence of calcified cartilage, causing extensive osteosclerosis, and in severe cases, closure of the medullary cavity, resulting in severe anemia. The disease is often familial, with the majority of cases being recessive. On the disease in view of the current cause of the disease is unknown, but there is a suspicion that it is a congenital developmental abnormalities lead to, so the disease is currently no effective preventive measures to provide, the current prevention and treatment of this disease focuses on the prevention of complications related to this disease. Therefore, early detection, early diagnosis and early treatment is the key to preventing further damage from this disease. Young men and women should learn about the family history of both parties before marriage and practice eugenics.