Breast tissue is a target organ for sex hormones, so women with ovarian function have cyclical tissue changes of breast tissue enlargement and recovery under the influence of endocrine hormones. In the hyperplasia period, some people may experience conscious breast pain, or touch some thickening of the breast, especially before the period is more obvious, after the period, the above symptoms can subside on their own, these are physiological changes, is not considered a disease and does not require treatment, do not easily put on the premenstrual breast pain ‘mastoproliferative disease hat. It is important to distinguish between physiological and pathological “breast enlargement”. If there is a lump in the breast every time you have a period and there is pain of varying lengths, some for months and some for years. This is caused by imperfect cyclical changes in the breast, which is a kind of physiological hyperplasia of the breast, and its histological changes include hyperplasia of fibrous tissue around the alveoli, ducts or lobules, irregular development of the lobules, and hyperplasia of epithelial cells in the alveoli or ducts. “Breast pain is the main clinical manifestation of physiological breast hyperplasia, so sometimes it is also called “breast pain”. Most of the physiological mastocytosis can heal on its own, some symptoms disappear completely after pregnancy and breastfeeding, and some heal on their own after 1 to 2 years of menopause. Pathological breast hyperplasia, also known as cystic hyperplasia of the breast, is histologically characterized by a high degree of expansion of the small milk ducts and the formation of cysts, hyperplasia of the epithelial cells of the milk ducts, and the occurrence of papillomas in most small and medium-sized milk ducts. It is important to pay great attention to this disease, so for mammary gland hyperplasia “must be treated differently, not generalized treatment.