Polymorphic rash of pregnancy is a benign, self-limiting skin condition that occurs during pregnancy. It usually occurs in the second trimester or during the early puerperium, and its clinical manifestations are urticarial papules, plaques, polycyclic erythematous eruptions, blisters, and target-shaped lesions that occur during pregnancy. The pathogenesis of gestational polymorphic rash is unknown and no definite conclusions have been drawn. The rash first occurs on the abdomen, mostly at stretch marks, and then may progress to the upper arms and thighs with intense pruritus. The lesions begin as papules and progress to target-like erythema, polycyclic erythema, and small blister-like lesions, but rarely occur on the palms of the hands, soles of the feet, or mucous membranes. Gestational polymorphic rash needs to be differentiated from intrahepatic cholestasis of pregnancy, herpetic impetigo, gestational itchy rash, gestational aspergillosis (also known as gestational herpes), and gestational itchy folliculitis. The first step is to explain in detail to the patient that this is a benign skin condition that occurs during pregnancy, which resolves spontaneously after a few weeks and does not increase the risk to the mother or fetus. Considering the self-limiting nature of the disease and the absence of serious complications, only symptomatic treatment is required. Topical anti-itch medications and emollients can be applied topically.