Patients over 80 years of age have been off-limits for surgery in the past because of their underlying diseases and organ declines. Recently, the Department of Gastrointestinal Surgery of Guangdong Provincial Hospital successfully performed a complex combined multi-organ resection for an 82-year-old cancer patient, and the patient has been discharged from the hospital. The tumor compressed the bile ducts and the old man developed black stool and jaundice. The old woman, Zhan, started to have black stool a month ago, and her body gradually lost weight, with a waxy complexion and weakness. The examination results showed that the old man was suffering from duodenal cancer with bleeding, and a huge cyst in the left kidney combined with internal bleeding and other symptoms were found. As the bile duct was compressed by the tumor, the old man developed obstructive jaundice and his skin and eyes were dyed yellow. According to Professor Wan Jin, Director of Gastrointestinal Surgery of Provincial Hospital of Traditional Chinese Medicine, duodenal cancer is a relatively rare malignant tumor, and pancreaticoduodenectomy is the largest operation in the field of abdominal surgery. If surgical resection is performed, Zhan’s mother-in-law suffers from hypertension, cardiac insufficiency and severe anemia, with only a quarter of the normal hematocrit and weak function of various organs, and her life is at risk every minute during the operation. After consultation with experts from all relevant specialties in the hospital, it was decided to first provide positive preoperative supportive treatment for Granny Zhan, correcting anemia, nutritional support, maintaining liver and kidney function, and improving cardiac insufficiency, so that the old man’s body could tolerate the surgery and minimize the risk of critical signs during and after the surgery. Afterwards, the expert group led by Wan Jin performed “pancreatic head duodenectomy combined with left kidney giant cyst opening and internal drainage ligation to stop the bleeding” on her. The surgery lasted for more than 4 hours, and the tumor and organs were removed and the left kidney cyst was drained through a window. Doctors removed several organs threatened by the tumor, including part of the stomach, duodenum, pancreatic head, common bile duct and gallbladder, and also performed internal drainage ligation to stop the bleeding on the huge cyst of the left kidney, and the tumor cut down was about five centimeters in diameter. Zhan was then transferred to the intensive care unit (ICU) for monitoring and treatment. Post-operative care for the elderly is a major difficulty. Due to her old age and frailty, and the fact that she had just had several organs removed, she was once in critical condition such as heart failure, hypertensive crisis and post-traumatic systemic inflammatory response syndrome, etc. After intensive treatment by the ICU expert treatment team, supplemented by TCM herbal therapy to strengthen the body resistance of the elderly, she finally passed the difficult time without danger. Doctors reminded that the elderly should not simply refuse to undergo surgery, but should comprehensively assess their physical condition to see whether they have the indications for surgery and whether they can tolerate surgery to decide what kind of surgery to take, improve their physical condition before surgery, and strengthen monitoring after surgery to carefully deal with possible problems with multiple organs.